AGBT Precision Health 2026: Advances in Precision Therapeutics and AI in Genomic Medicine.
Three days, seven scientific sessions, two pre-conference workshops and a poster program. Talks marked abstract-selected were chosen from submitted abstracts rather than invited. Unless otherwise noted, sessions took place in the Commodore Ballroom. The 2027 program will be published separately.
Location
Loews Coronado Bay Resort, Coronado, California
Sessions
Seven, plus two pre-conference workshops
Speakers
Featured and abstract-selected
Monday, September 14
Day one · Foundations and frontiers of genomic medicine
The evening grounds attendees in where genomic medicine stands today and where it is headed, setting a shared framework for the advances in discovery, clinical application and emerging technology explored through the rest of the meeting.
Pre-conference workshops
Hands-on, expert-led sessions exploring tools, case studies and practical approaches shaping precision health research and implementation.
1:00 – 2:30 p.m.
Exposomics in Precision Health
Gary Patti, Washington University in St. Louis; Chirag Patel, Harvard University; Maayan Levy, Stanford University; Donghai Liang, Emory University. Moderator: Stephen B. Montgomery, Stanford University
2:30 – 4:00 p.m.
Perspectives from Expert Stakeholders Across Interventional Genomics in Rare DiseaseSponsored by Illumina
Olivia Kim-McManus, University of California, San Diego; Vaidehi Jobanputra, New York Genome Center; Lauren Black, Charles River. Moderator: Katarzyna Ellsworth, Rady Children’s Institute for Genomic Medicine
4:00 – 5:00 p.m.
Welcome cocktail hour
Sponsor Promenade, Constellation Foyer
Session I · Genomic Medicine Today and Tomorrow
This opening session reflects on the evolution of genomic medicine from foundational discoveries to present-day clinical impact. Speakers examine key scientific and translational milestones while offering perspectives on the opportunities and challenges shaping the future of genomic and precision medicine.
Session chair: Richard Wilson, Nationwide Children’s Hospital, meeting co-chair
5:00 – 5:15 p.m.
Opening remarks and welcome, and the AGBT Precision Health Service Award
Richard Wilson, Nationwide Children’s Hospital. Award presented by Len Pennacchio, DOE Joint Genome Institute, Lawrence Berkeley National Laboratory. Recipient: Michael Talkowski
5:15 – 5:45 p.m.
A scientist’s perspective on precision medicine
Aravinda Chakravarti, NYU Grossman School of Medicine
5:45 – 6:15 p.m.
Prenatal aneuploidy screening and incidental detection of cancer: everything all at once
Diana Bianchi, NICHD at the National Institutes of Health, former director
6:15 – 6:45 p.m.
Precision health in a genetically diverse health system
Dan Geschwind, University of California, Los Angeles
6:45 – 7:00 p.m.
Long-read multi-ome sequencing resolves the gene regulatory mechanism of a complex structural variant causing an X-linked congenital ataxiaAbstract-selected
Christy LaFlamme, University of Washington
7:00 – 9:00 p.m.
Welcome reception and dinnerSponsored by SeqOne
Bay Terrace
Tuesday, September 15
Day two · Intelligence, ethics and discovery in genomic medicine
Advances in artificial intelligence, computational genomics and rare disease research, alongside the ethical and societal considerations shaping their translation into precision health.
7:30 – 9:00 a.m.
Breakfast
Commodore Terrace
7:30 – 9:00 a.m.
AGBT Women’s Networking BreakfastSponsored by Illumina
The inaugural women’s networking event at Precision Health, focused on connection, mentorship and shared experience among women advancing science and precision health. Avalon
Session II · AI for Genomic Medicine and Diagnostics
How artificial intelligence and advanced computational methods are reshaping the interpretation of genomic data and its application in clinical care, from variant interpretation and gene regulation to disease biology, with particular attention to neurological disease.
Session chair: Katie Pollard, Gladstone Institutes
9:00 – 9:25 a.m.
Machine learning for dynamic and context-specific genetic effects
Alexis Battle, Johns Hopkins University
9:25 – 9:50 a.m.
Building AI systems for hypothesis evaluation and target assessment
Sara Mostafavi, Genentech
9:50 – 10:15 a.m.
Big data, real patients: AI and ML strategies for EHR-linked biobanks
Marylyn Ritchie, Medical University of South Carolina
10:15 – 10:30 a.m.
Explanation-first large language model reanalysis improves diagnostic yieldAbstract-selected
Catherine Brownstein, Boston Children’s Hospital
10:30 – 11:00 a.m.
Coffee break
Sponsor Promenade, Constellation Foyer
Session III · The Great Debate: Modernizing Informed Consent for Genomic Medicine
As genomic medicine expands beyond specialist research settings into routine clinical care and large-scale data-sharing, informed consent has become one of the field’s most pressing challenges. Panelists debate whether current consent models are fit for purpose, and how digital and AI-enabled tools could support more scalable, inclusive and trustworthy participation.
Moderators: Heidi Rehm, Broad Institute of MIT and Harvard, and Massachusetts General Hospital; Eric Green, chief medical officer, Illumina
11:00 – 11:50 a.m.
The Great Debate
Panelists: Kyle Brothers, Norton Children’s Research Institute; Moran Snir, NEST Genomics; Jenny Taylor, University of Oxford; Monica Wojcik, Boston Children’s Hospital
11:50 a.m. – 12:30 p.m.
Next Gen Leadership AwardsSponsored by Illumina
Awardees share their work and what the recognition means to them. Presented by Gail Jarvik, University of Washington, Seattle, meeting co-chair, and Eric Green, chief medical officer, Illumina
1:00 – 2:00 p.m.
Dessert with sponsors
Sponsor Promenade, Constellation Foyer
Sponsor talks
Industry partners advancing tools, platforms and diagnostics supporting genomic innovation.
Moderator: Jenny Taylor, University of Oxford
2:05 – 2:25 p.m.
From data to diagnosis: leveraging scale, diversity and AI-informed tools to advance variant prioritization, classification and interpretationGold · GeneDx
Flavia Facio, medical affairs director, technologies platform, GeneDx
2:25 – 2:40 p.m.
Characterizing repeat expansions with electronic genome mappingSilver · Nabsys
Michael Gallagher, software applications scientist, Nabsys
2:40 – 2:50 p.m.
From platform to practice: twelve months of US clinical deployment across the NICU, newborn screening and community genomicsBronze · SeqOne
Michael Vishnevetsky, VP of business development, North America, SeqOne
2:50 – 3:00 p.m.
After the genome: bringing precision medicine to life with patient-derived organoidsBronze · MilliporeSigma
Haiying Grunenwald, head of biology R&D, MilliporeSigma
3:00 – 3:10 p.m.
Confessions of an instrument maker: thinking outside the box and past the plexBronze · Singular Genomics
Kieren Patel, chief business officer, Singular Genomics
Session IV · Rare Disease Mechanisms and Innovation
Recent advances in understanding and addressing rare genetic diseases, spanning disease mechanism discovery, functional genomics and the translation of insight into therapeutic strategy.
Session chair: Stephen Kingsmore, Cleveland Clinic
3:10 – 3:35 p.m.
You are your own best reference: resolving the function of germline and somatic variation using donor-specific assemblies
Andrew Stergachis, University of Washington, Seattle
3:35 – 4:00 p.m.
New frontiers in newborn genomics: everything everywhere all at once
Monica Wojcik, Boston Children’s Hospital
4:00 – 4:20 p.m.
Poster flash talksAbstract-selected
Brief presentations from selected poster authors
4:30 – 8:00 p.m.
Poster session, sponsor reception and dinner
Hors d’oeuvres and posters 4:30 to 6:30 p.m., odd numbers first, even numbers from 5:30. Dinner and desserts 6:30 to 8:00 p.m. Commodore Ballroom E, Constellation Ballroom and Foyer
8:00 – 11:00 p.m.
Sponsor social
Sponsor Promenade, Constellation Foyer
Wednesday, September 16
Day three · From insight to impact in genomic medicine
How advances in genomic medicine move from discovery to real-world impact, spanning clinical implementation, patient and family perspectives, and the development of precision therapies.
6:30 – 7:30 a.m.
Rise and Shine with AGBT
Optional activity
7:30 – 9:00 a.m.
Breakfast
Commodore Terrace
Session V · Implementation of Precision Health and Clinical Impacts
How genomic insight is being translated into clinical care, covering genomic diagnostics, personalized therapies, clinical sequencing and approaches to interpreting genetic variation.
Session chair: Heather Mefford, St. Jude Children’s Research Hospital
9:00 – 9:25 a.m.
Transformative technologies and clinical translation
Niall Lennon, Broad Institute of Harvard and MIT
9:25 – 9:50 a.m.
Personalized gene-editing therapies
Kiran Musunuru, University of Pennsylvania
9:50 – 10:15 a.m.
From genomic diagnostics to therapeutics: the UK’s rare therapies launch pad
Jenny Taylor, University of Oxford
10:15 – 10:40 a.m.
Universal exome sequencing in critically ill adults: a diagnostic yield of 25% and race-based disparities in access to genetic testing
Theodore G. Drivas, University of Pennsylvania
10:40 – 10:55 a.m.
Biobank-scale molecular profiling refines interpretation of rare recessive alleles in Mendelian disease genesAbstract-selected
Evin Padhi, Stanford University
10:55 – 11:30 a.m.
Coffee break
Sponsor Promenade, Constellation Foyer
Session VI · Patient’s Perspective
Precision health brought into human focus through the lived experience of childhood cancer, survivorship and participation in genomic research. Patient, family and physician perspectives explore how genomic medicine shapes care, research and partnership over time.
11:30 a.m. – 12:15 p.m.
Fireside chat: a life shaped by precision health
Moderator: Richard Wilson, executive director, the Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children’s Hospital. Guests: a patient, her mother, and Samara Potter, director of clinical cancer genomics outreach, Institute for Genomic Medicine, Nationwide Children’s Hospital
Session VII · Advances in Therapeutic Discovery to Development
The translation of genetic insight into therapeutic strategy, spanning human genetics, functional studies, target discovery, regulation and individualized approaches to treatment.
Session chair: Bimal Chaudhari, Nationwide Children’s Hospital
1:45 – 2:10 p.m.
Adventures in human genetics: improving drug discovery and development through analysis of millions of human genomes
Goncalo Abecasis, Regeneron Genetics Center
2:10 – 2:35 p.m.
Shaping the future of genomic medicine: definitions, regulation and equitable access
Alison Niewiarowska, UK Medicines and Healthcare Products Regulatory Agency
2:35 – 3:00 p.m.
Functional characterization and therapeutic targeting of gene regulatory elements
Nadav Ahituv, University of California, San Francisco
3:00 – 3:15 p.m.
High-throughput characterization of excitatory and inhibitory gene regulatory sequences for neuronal precision gene therapyAbstract-selected
Sarah Fong, University of California, San Francisco
3:15 – 3:30 p.m.
Identification of early exhaustion-specific regulatory programs in T cellsAbstract-selected
Xinru Zhang, Gladstone Institutes
3:30 – 3:45 p.m.
Closing reflections
Gail Jarvik, University of Washington, Seattle, and Stephen Montgomery, Stanford University, meeting co-chairs
6:00 – 9:00 p.m.
Sips & Science: a sunset dinner cruise with AGBT
A private yacht cruise with dinner, drinks and coastal sunset views, bringing attendees together across institutions and specialties. RSVP required, space limited
