Steve Reilly is an Assistant Professor Genetics at Yale University School of Medicine. The Reilly lab builds experimental functional genomics and computational tools to understand how non-coding genetic variants lead to phenotypes. He is especially interested in variants that have undergone evolutionary selection in ancient global populations, but remain impactful for modern human traits and health. Dr. Reilly is an member of large-scale scientific consortia such as ENCODE and Zoonomia, where he has applied high-throughput reporter assays and CRISPR screens to determine the regulatory impact of human variation. His lab seeks to build the requisite multi-dimensional datasets and machine learning approaches to better understand the logic of cis-regulatory grammar.