Sean Eddy is a computational biologist at Harvard University. He is a Howard Hughes Medical Institute investigator and the Ellmore C. Patterson Professor of Molecular & Cellular Biology and of Applied Mathematics. Before his recent move to Harvard in 2015, he was a group leader at HHMI’s Janelia Research Campus near Washington DC. He is interested in deciphering the evolutionary history of life by comparison of genomic DNA sequences. His expertise is in the development of computational algorithms and software tools for biological sequence analysis. He is the author of the HMMER and Infernal software tools for sequence homology analysis, and is a coauthor of the book Biological Sequence Analysis (Cambridge University Press, 1998). He serves as an advisor to several foundations and agencies in the US and UK, often on matters of large scale computation and data analysis in the biological sciences.