Gregg Semenza

Dr. Gregg Semenza is a physician and scientist known for his investigations of how cells use and regulate oxygen and for the discovery of hypoxia-inducible factor (HIF), a molecule that is activated by reduced oxygen availability in cells and that plays a critical role in enabling cells to survive in certain disease states.

Semenza’s research opened a door for the investigation and development of novel treatments for diseases such as cancer and ischemic cardiovascular disease, in which reduced oxygen availability is a major feature of disease. For his discoveries he was awarded the 2019 Nobel Prize for Physiology or Medicine (shared with American scientist William G. Kaelin, Jr., and British scientist Sir Peter J. Ratcliffe).