Josh Denny is the Chief Executive Officer of the National Institutes of Health’s All of Us Research Program. He has been involved in All of Us from its inception, first as a member of the Advisory Committee to the (NIH) Director Precision Medicine Initiative Working Group, which developed the program’s initial scientific blueprint. He led the program’s initial prototyping project and served as the principal investigator for the All of Us Data and Research Center.

As a physician scientist, Josh is deeply committed to improving patient care through the advancement of precision medicine. Before joining the NIH, Josh was a Professor of Biomedical Informatics and Medicine, Director of the Center for Precision Medicine, and Vice President for Personalized Medicine at Vanderbilt University Medical Center. In his roles at VUMC, he was both a practicing internist and a researcher. His research interests include use of electronic health records (EHRs) and genomics to better understand disease and drug response. He also led efforts implementing precision medicine to improve patient outcomes. Josh was a leader in the development of phenome‐wide association studies (PheWAS) and phenotype risk scores. He served as PI for Vanderbilt sites in the Electronic Medical Records and Genomics (eMERGE) Network, Pharmacogenomics Research Network (PGRN), and the Implementing Genomics into Practice (IGNITE) Network.

He is an elected member of the National Academy of Medicine, the American Society for Clinical Investigation, and the American College of Medical Informatics.

Mary De Silva leads the Population Health team which directs Wellcome’s funding of population health research in the UK and in low- and middle-income countries.

Our portfolio spans aetiological research to understand the individual and wider determinants of health, and translational science to develop and test effective and scalable interventions to prevent and treat ill health, ensure health systems are robust, and that evidence is translated into policy and practice.

Current strategic areas of interest include Wellcome’s Longitudinal Population Studies Strategy, catalysing advances in nutrition, health of the public and multi-morbidity research, and strengthening the pathways through which research evidence improves health. I also co-developed and sit on the Programme Board for the Mental Health Priority Area at Wellcome, a new research investment of £200 million.

Before joining Wellcome I was Deputy Director of the Centre for Global Mental Health at the London School of Hygiene and Tropical Medicine. My research included the design and evaluation of complex interventions to improve mental health in low- and middle-income countries, implementation research to ensure that these interventions are scalable and sustainable, and policy influence work to encourage the translation of evidence into policy and practice. I also co-founded and led the Mental Health Innovation Network (http://www.mhinnovation.net/).

Sekar Kathiresan is co-founder and chief executive officer of Verve Therapeutics and serves on the company’s board of directors. He is a preventive cardiologist who has made groundbreaking discoveries of cardioprotective genetic mutations, which confer resistance to cardiovascular disease. Prior to joining Verve, he served as director of the Massachusetts General Hospital (MGH) Center for Genomic Medicine and was the Ofer and Shelly Nemirovsky MGH Research Scholar. He also served as director of the Cardiovascular Disease Initiative at the Broad Institute and was professor of medicine at Harvard Medical School. His research laboratory focused on understanding the inherited basis for blood lipids and myocardial infarction and using these insights to improve preventive cardiac care. Among his scientific contributions, he has helped highlight new biological mechanisms underlying heart attack, discovered mutations that protect against heart attack risk, and developed a genetic test for personalized heart attack prevention. He was honored with a Distinguished Scientist Award from the American Heart Association in 2017 and the 2018 Curt Stern Award from the American Society of Human Genetics. In tandem with his research, his clinical focus was the primary prevention of myocardial infarction in individuals with a family history of heart attack. He graduated summa cum laude with a B.A. in history from the University of Pennsylvania and received his M.D. from Harvard Medical School. He completed his clinical training in internal medicine and cardiology at MGH and his postdoctoral research training in human genetics at the Framingham Heart Study and the Broad Institute.

Joyce Tung is Vice President of Research at 23andMe, and manages the 23andMe research team, which is responsible for new research methods and tools development, genetics discovery for therapeutics target identification and validation, academic and industry research collaborations, and the ethical conduct of 23andMe’s consumer-based research program. Before joining 23andMe in 2007. Joyce was a postdoctoral fellow at Stanford University, where she studied the genetics of mouse and human pigmentation. She graduated from Stanford with honors and distinction with a B.S. in Biological Sciences and a minor in Computer Science, and earned her Ph.D. in Genetics from the University of California, San Francisco where she was a National Science Foundation graduate research fellow.