2022 Agenda
June 6, 2022
10:00 a.m. – 4:00 p.m.
Bonnet Creek Ballroom Salon I-VI
Pre-Conference
10:00 a.m. – 11:00 a.m.
Floridian Ballroom
McDonnell Genome Institute, Washington University
Human Pangenome Reference Consortium (HPRC)
Valerie Schneider, Ph.D., National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
“Navigating the changing human genome resource landscape: GRCh38, T2T-CHM13 and HPRC assemblies”
Arang Rhie, Ph.D., National Human Genome Research Institute, National Institutes of Health
“A finished Y chromosome from HG002 completes the T2T-CHM13 reference”
Xian Chang, UC Santa Cruz Genomics Institute
“The HPRC human pangenome graph: updates and applications”
12:00 p.m. – 4:00 p.m.
Bonnet Creek Ballroom
NanoString Spatial Multiomics Symposium
Christopher Mason, PhD, Professor; Director, WorldQuant Initiative, Weill Cornell Medicine
Joseph Beechem, PhD, Chief Scientific Officer,
Sr. Vice President, R&D, NanoString Technologies
Grant R. Kolar, M.D., PhD, Associate Research Professor, Saint Louis University School of Medicine
Arutha Kulasinghe, PhD, NHMRC Research Fellow, The University of Queensland
Kevin Wei, M.D., PhD, Assistant Professor of Medicine, Brigham and Women’s Hospital
Miranda Orr, Ph.D., Assistant Professor, Gerontology and Geriatric Medicine, Wake Forest University School of Medicine
Scientific Program
8:00 a.m. – 7:00 p.m.
Bonnet Creek Center Foyer
Meeting Registration / Hospitality Desk
Floridian Ballroom Salon A-L
Plenary Session: Genomics I (Eric Green, National Human Genome Research Institute, Chair)
5:00 p.m. – 5:05 p.m.
Opening Remarks
5:05 p.m. – 5:35 p.m.
Euan Ashley
Stanford University
“Long read genome sequencing: speeding towards the clinic”
5:35 p.m. – 6:05 p.m.
Olga Troyanskaya
Princeton University, and Deputy Director for Genomics at the Flatiron Institute, Simons Foundation
6:05 p.m. – 6:25 p.m.
William Hwang (Abstract Selected)
Massachusetts General Hospital
“Multicellular spatial neighborhoods in pancreatic cancer are remodeled by neoadjuvant treatment”
6:25 p.m. – 6:45 p.m.
Kevin King (Abstract Selected)
University of California, San Diego
“Defining the ischemic borderzone with single cell spatial resolution”
7:00 p.m. – 10:00 p.m.
Hilton Pool
Welcome Reception
June 7, 2022 (Morning)
7:30 a.m. – 9:00 a.m.
Waldorf Golf Pavilion
Breakfast
8:00 a.m. – 7:00 p.m.
Bonnet Creek Ballroom West Foyer
Meeting Registration / Hospitality Desk
Floridian Ballroom Salon A-L
Plenary Session: Evolutionary Genomics
Stacey Gabriel, Broad Institute of MIT and Harvard, Chair
9:00 a.m. – 9:30 a.m.
Mary O’Connell
University of Nottingham, UK
“On the malleability of protein function”
9:30 a.m. – 10:00 a.m.
Simone Immler
University of East Anglia, UK
“Consequences of haploid selection in sperm”
10:00 a.m. – 10:30 a.m.
Elinor Karlsson
University of Massachusetts Medical School, and director of Vertebrate Genomics at the Broad Institute of MIT and Harvard
“The future of comparative genomics: finding meaning in sequence in a million genome age”
10:30 a.m. – 11:00 a.m.
Coffee Break
Sponsor Promenades
11:00 a.m. – 11:30 a.m.
Mike Snyder
Stanford University
“Transformative approaches to analyze genomes using machine learning reveals the genetic basis of complex diseases”
11:30 a.m. – 11:50 p.m.
Poster Flash Talks
June 7, 2022 (Afternoon)
12:00 p.m. – 1:30 p.m.
Bonnet Creek Ballroom Salon I-VI
Gold Sponsor – Resolve Biosciences Workshop and Lunch
Jason T. Gammack, CEO and Co-founder of Resolve Biosciences
Prof. Dr. Nikolaus Rajewsky Berlin Institute for Medical Systems Biology
Michael Snyder, Ph.D. Department of Genetics, Stanford School of Medicine, Stanford University.
“Context matters: Spatial- temporal subcellular gene expression patterns in systems biology and human cell atlases through spatial genomics.”
12:00 p.m. – 1:30 p.m.
Outdoor Waldorf Promenade
AGBT Lunch
1:30 p.m. – 3:00 p.m.
Bonnet Creek Ballroom Salon VII-XII
Poster Session with Coffee & Dessert
Floridian Ballroom Salon A-L
Plenary Session: Genomics II
Martin Hirst, University of British Columbia, Chair
3:00 p.m. – 3:30 p.m.
Trevor Lawley
Wellcome Sanger Institute and Chief Scientific Officer, Microbiotica
“Making medicines from the human microbiome”
3:30 p.m. – 4:00 p.m.
Alison Van Eenennaam
University of California, Davis
“Functional analysis and characterization of the hornless phenotype in cattle using genome editing”
4:00 p.m. – 4:20 p.m.
Kiana Aran (Abstract Selected)
Cardea Bio
“From CPUs to BPUs: A new generation of transistors for rapid amplification-free genotyping”
4:20 p.m. – 4:40 p.m.
Can Cenik (Abstract Selected)
University of Texas, Austin
“Single cell quantification of ribosome occupancy in early mouse development”
June 7, 2022 (Evening)
5:00 p.m. – 7:15 p.m.
Dinner on your own
5:30 p.m. – 7:15 p.m.
Signature Island
Women’s Networking Event
Bonnet Creek Ballroom Salon I-VI
Concurrent Session: Cancer
Kim Doheny, Johns Hopkins University School of Medicine, Chair
7:30 p.m. – 7:50 p.m.
Lukas Chavez
University of California, San Diego
“The landscape of extrachromosomal circular DNA in medulloblastoma”
7:50 p.m. – 8:10 p.m.
Quan Nguyen
Institute for Molecular Bioscience, The University of Queensland
“Building a spatial single-cell multi-omics atlas and cellular interactome for skin cancer”
8:10 p.m. – 8:30 p.m.
Michael Quail
Wellcome Sanger Institute
“NanoSeq: A high-throughput pipeline for the detection of somatic mutations at single-molecule resolution”
8:30 p.m. – 8:50 p.m.
Billy Lau
Stanford University School of Medicine
“Massively parallel nanopore sequencing of circulating tumor DNA enables robust quantification of tumor burden”
8:50 p.m. – 9:10 p.m.
Edwin Cuppen
Hartwig Medical Foundation
“Routine whole genome sequencing-based cancer diagnostics for precision medicine”
9:10 p.m. – 9:30 p.m.
Panagiotis Karras
VIB Center for Cancer Biology
“Dissecting the melanoma ecosystem at single-cell resolution using Molecular CartographyTM”
Floridian Ballroom Salon A-L
Concurrent Session: Computational Biology
Mike Zody, New York Genome Center, Chair
7:30 p.m. – 7:50 p.m.
Kristian Cibulskis
The Broad Institute
“Optimizing large-scale joint callsets for All of Us”
7:50 p.m. – 8:10 p.m.
Melanie Kirsche
Johns Hopkins University
“Jasmine: Population-scale structural variant comparison and analysis”
8:10 p.m. – 8:30 p.m.
Vinicius Medeiros Fava
McGill University
“A system biology approach identifies candidate drugs to reduce mortality in severely ill COVID-19 patients”
8:30 p.m. – 8:50 p.m.
Tanner Jensen
Stanford University
“Integrative analysis of long-read and functional genomics data improves prioritization of pathogenic variants in exome-negative, rare-disease patients”
8:50 p.m. – 9:10 p.m.
Jialong Jiang
California Institute of Technology
“Spin-network models identify and predict human immunomodulatory drug response signatures in high-throughput single-cell mRNA-seq data”
9:10 p.m. – 9:30 p.m.
Chandrima Bhattacharya
Weill Cornell Medicine
“Microbial survival in the Anthropocene: Bioremediation and biomining potential of a superfund site – the Gowanus Canal”
9:30 p.m.
CLICK2WIN (Formerly Passport to Prizes)
Sponsor Promenades
June 8, 2022 (Morning)
7:30 a.m. – 9:00 a.m.
Waldorf Golf Pavilion
Breakfast
8:00 a.m. – 7:00 p.m.
Bonnet Creek Ballroom West Foyer
Hospitality Desk
Floridian Ballroom Salon A-L
Plenary Session: Genetics I
Federica Di Palma, Genome British Columbia, Chair
9:00 a.m. – 9:30 a.m.
Martin Hirst
University of British Columbia
“SMARCB1 loss is associated with compartment switching and sensitivity to NSD1/2 inhibition”
9:30 a.m. – 10:00 a.m.
Zach Lippman
Cold Spring Harbor Laboratory (CSHL) and Howard Hughes Medical Institute (HHMI)
“Dynamic diversification of gene duplications in shaping trait variation”
10:00 a.m. – 10:20 a.m.
Lesley Shirley (Abstract Selected)
Wellcome Sanger Institute
“Large-scale whole-genome sequencing of SARS-CoV-2 at the Sanger Institute: The COVID-19 Genomics UK consortium”
10:20 a.m. – 11:00 a.m.
Coffee Break
Sponsor Promenade
11:00 a.m. – 11:20 a.m.
Samantha Sholes (Abstract Selected)
Johns Hopkins University School of Medicine
“Nanopore sequencing telomere length measurement method reveals chromosome specific telomere lengths”
11:30 a.m. – 11:50 a.m.
Poster Flash Talks
June 8, 2022 (Afternoon)
12:00 p.m. – 2:00 p.m.
Bonnet Creek Ballroom Salon I-VI
Silver Sponsor Workshops and Lunch
12:00 p.m. – 1:00 p.m.
Silver 1 Sponsor Workshop – Ultima Genomics
Gilad Almogy, CEO and Co-Founder, Ultima Genomics
“Welcome and introduction”
Doron Lipson, CSO, Ultima Genomics
“Enabling genomic analysis at scale: applications and collaborations”
Stacey Gabriel, Broad Institute
“An evaluation of the Ultima Genomics sequencing platform: high-throughput sequencing at low-cost”
Reuben Saunders, Whitehead Institute
“Mapping the genetic landscape of complex cellular phenotypes with genome-scale Perturb-Seq”
Erez Lieberman Aiden, Baylor College of Medicine
“Generating 3D maps of the human genome at basepair resolution using the Ultima Genomics platform reveals principles of enhancer-promoter wiring”
1:05 p.m. – 2:05 p.m.
Silver 2 Sponsor Workshop and Lunch – Element Biosciences
Moderated by Shawn Levy
Andrew Carroll (Deep Variant), Chris Mason (Weil Cornell), Sheila Dodge (Broad), and Mike Previte (Element Biosciences)
“Elements of freedom: astronauts, forensics, and state of the art genomics”
12:00 p.m. – 2:00 p.m.
Outdoor Waldorf Promenade
AGBT Lunch
Floridian Ballroom Salon A-L
Bronze Sponsor Workshops
Stephen Montgomery, Stanford University School of Medicine, Chair
2:15 p.m. – 2:35 p.m.
Bronze 1 Sponsor – Twist Bioscience
Emily Leproust, PhD
“Continuing the relentless pursuit of precision medicine – new tools for cancer genomics research”
2:35 p.m. – 2:55 p.m.
Bronze 2 Sponsor – PacBio
David Miller, Vice President, Product Marketing, PacBio
“Sequencing by Binding (SBB®) delivers unprecedented NGS accuracy”
2:55 p.m. – 3:15 p.m.
Bronze 3 Sponsor – DNA Script
Thomas Ybert and Xavier Godron
“Same-Day enzymatic DNA synthesis: now print primers and labeled probes using the SYNTAX System”
3:15 p.m. – 3:30 p.m.
Bronze 4 Sponsor – Integrated DNA Technologies
Dr. Steven Henck, Vice President of R&D, IDT
“Introducing IDT’s more complete NGS portfolio. xGenTM NGS – made for you.”
3:30 p.m. – 3:45 p.m.
Bronze 5 Sponsor – Miroculus
Fay Christodoulou
“Miro Canvas: an automation solution for every lab”
3:45 p.m. – 4:00 p.m.
Bronze 6 Sponsor – Agilent
Bellal Moghis, Director of Marketing
“Paving the way forward | Leveraging Agilent’s innovations to achieve new heights”
4:00 p.m. – 4:15 p.m.
Bronze 7 Sponsor – New England Biolabs
Bradley W. Langhorst, Ph.D., Product Development Group Leader
“Clearing the CoV Fog: Pandemic LAMP and Sequencing at NEB”
4:15 p.m. – 4:27 p.m.
Bronze 8 Sponsor – Bruker
Mark R. Munch, Ph.D. – President Bruker NANO & CEO Acuity Spatial Genomics, Inc.
“Bruker presents novel cutting-edge solutions for deeper, quantitative analysis of spatial biology and single cell omics”
4:27 p.m. – 4:39 p.m.
Bronze 9 Sponsor – Bionano Genomics
Alka Chaubey, Ph.D., Chief Medical Officer, Bionano
“OGM + NGS for transforming genome biology. The FUTURE is Bright!”
4:40 p.m. – 6:10 p.m.
Bonnet Creek Ballroom Salon VII-XII
Poster Session and Wine Reception
June 8, 2022 (Evening)
6:15 p.m. – 7:25 p.m.
Outdoor Waldorf Promenade
AGBT Dinner
Floridian Ballroom Salon A-L
Concurrent Session: Technology
Chris Mason, Weill Cornell Medicine, Chair
7:30 p.m. – 7:50 p.m.
Chongyuan Luo
University of California, Los Angeles
“In situ single-cell epigenomic profiling by photonic-indexing sequencing”
7:50 p.m. – 8:10 p.m.
Sheridan Cavalier
Johns Hopkins School of Medicine Dept of Neuroscience
“Single-cell transcript isoform sequencing of the actived adult mouse hippocampus with 10x Genomics and Oxford Nanopore”
8:10 p.m. – 8:30 p.m.
George Emanuel
Vizgen
“Molecular atlassing with MERSCOPE: A new spatial transcriptomics technique accurately reveals the organization of the mouse brain transcriptome”
8:30 p.m. – 8:50 p.m.
Heonseok Kim
Stanford University
“A single cell CRISPR and nanopore long read approach for modifying mRNA sequence and generating novel transcript isoforms”
8:50 p.m. – 9:10 p.m.
Joseph Beechem
Nanostring Technologies Inc.
“High-plex (> 1000), multi-omic (RNA plus protein), spatial molecular imaging with sub-cellular resolution in FFPE tissue”
9:10 p.m. – 9:30 p.m.
Christopher Grochowski
Baylor College of Medicine
“Resolving complex genomic inversion structures”
Bonnet Creek Ballroom Salon I-VI
Concurrent Session: Biology
Penelope Bonnen, Baylor College of Medicine, Chair
7:30 p.m. – 7:50 p.m.
Jeffrey Shaman
Coriell Life Sciences
“Results and reflections of a real-world implementation of a pharmacogenomics-empowered comprehensive medication management (CMM) program”
7:50 p.m. – 8:10 p.m.
Pengfei Liu, Baylor College of Medicine
“Analytical evaluation of clinical whole genome sequencing with a highly novel, vastly cheaper DNA sequencing-by-synthesis technology”
8:10 p.m. – 8:30 p.m.
Varuna Chander
Baylor College of Medicine
“Somatic mosaicism and cardiovascular disease: Uncovering hidden genetic etiology with clinical Implications”
8:30 p.m. – 8:50 p.m.
Eloi Schmauch
Massachusetts Institute of Technology, University of Eastern Finland, MIT and Harvard, Broad Institute
“Single-cell spatio-transcriptional dissection of human heart in health and coronary artery disease reveals cell-type-specific driver genes and pathways”
8:50 p.m. – 9:10 p.m.
Alma Andersson
Science For Life Laboratory (SciLifeLab) and Royal Institute of Technology (KTH)
“Building common coordinate frameworks for spatial transcriptomics data to promote modelling of large and diverse datasets”
9:10 p.m. – 9:30 p.m.
Hilde Nelissen
Ghent University, Department of Plant Biotechnology and Bioinformatics / VIB Center for Plant Systems Biology
“Molecular CartographyTM reveals novel cell types and gene functions in the maize shoot apex”
June 9, 2022 (Morning)
7:30 a.m. – 9:00 a.m.
Waldorf Golf Pavilion
Breakfast
8:00 a.m. – 7:00 p.m.
Bonnet Creek Ballroom West Foyer
Hospitality Desk
Floridian Ballroom Salon A-L
Plenary Session: Genetics II
Len Pennacchio, Lawrence Berkeley National Laboratory and DOE Joint Genome Institute, Chair
9:00 a.m. – 9:30 a.m.
Neil Hanchard
National Human Genome Research Institute
“MIA: uncaptured sequence variation in african populations”
9:30 a.m. – 10:00 a.m.
Alicia Zhou
Chief Science Officer, Color
“Deploying genomics at population scale”
10:00 a.m. – 10:20 a.m.
Federica Di Palma (Abstract Selected)
Genome British Columbia, Vancouver CA / University of East Anglia, UK
“Evolution of regulatory networks associated with traits under selection in cichlids”
10:20 a.m. – 11:00 a.m.
Coffee Break
Sponsor Promenades
11:00 a.m. – 11:20 a.m.
Joshua Cohen (Abstract Selected)
Johns Hopkins University School of Medicine
“Detection of low-frequency DNA variants by targeted sequencing of the Watson and Crick strands”
11:20 a.m. – 11:40 a.m.
Stephanie Yan (Abstract Selected)
Johns Hopkins University
“A complete reference genome improves analysis of human genetic variation”
12:00 p.m. – 1:00 p.m.
Bonnet Creek Ballroom Salon I-VI
Silver 3 Sponsor Workshop and Lunch – 10 X Genomics
Peter Smibert, Mike Gibbons, Augusto Tentori and Francesca Meschi
“The next generation of single cell and spatial technologies”
12:00 p.m. – 1:30 p.m.
Outdoor Waldorf Promenade
AGBT Lunch
June 9, 2022 (Afternoon)
Floridian Ballroom Salon A-L
Plenary Session: Technology
Penelope Bonnen, Baylor College of Medicine, Chair
1:30 p.m. – 2:00 p.m.
Fei Chen
The Broad Institute of MIT and Harvard
“Tissue genomics: placing genomic measurements in context”
2:00 p.m. – 2:30 p.m.
Steven Reilly
Yale School of Medicine
“Towards understanding the impact of all variants: identifying 3′UTR causal variants for human disease and evolution”
2:30 p.m. – 2:50 p.m.
Gilad Almogy, Ultima Genomics
“Novel large-scale sequencing platform using mostly-natural sequencing by synthesis”
2:50 p.m. – 3:20 p.m
Floridian Ballroom Foyer
Coffee Break
3:20 p.m. – 3:40 p.m.
Ghamdan Al-Eryani (Abstract Selected)
Garvan Institute of Medical Research
“Multi-omic integration of single-cell and spatial RNA and protein analysis identifies novel tumor-infiltrating lymphocyte phenotypes”
3:40 p.m. – 4:00 p.m.
Shruti Iyer (Abstract Selected)
Cold Spring Harbor Laboratory/Stony Brook University
“ACME: An Affinity-based Cas9 Mediated Enrichment method for targeted nanopore sequencing”
4:00 p.m. – 4:20 p.m.
Christopher Vollmers (Abstract Selected)
University of California, Santa Cruz
“Illumina but with Nanopore”
4:20 p.m. – 4:30 p.m.
CLICK2WIN Winner Announced
Closing Comments and Meeting Feedback
6:00 p.m. – 10:00 p.m.
Waldorf Golf Pavilion
Farewell Dinner Party
Luau Theme
Join us at AGBT’s flagship event for bringing together global leaders, researchers, and innovators.
