Dr. Len Pennacchio is a Senior Scientist at the Lawrence Berkeley Laboratory (LBL), Deputy Director of the Joint Genome Institute, and Adjunct Professor at the University of California Berkeley. He received his PhD in Genetics from Stanford University and served as an Alexander Hollaender Distinguished Fellow at LBL. He has authored over 140 publications and received the Presidential Early Career Award for Scientists and Engineers (PECASE) from the White House for his contributions to the Human Genome Project and understanding mammalian gene regulation in vivo. Dr. Pennacchio has an extensive background in mammalian genetics and genomics as well as with DNA sequencing technologies and their application to address outstanding issues in both the biomedical, energy, and environment sectors. He serves in numerous advisory roles such as NHGRI’s Genome Sequencing Program and the Centre for Genomic Research at the University of Liverpool and is an Instructor for the Leena Peltonen School of Human Genomics. He also is an Organizer and Co-Chair of both annual Advances in Genome Biology & Technology (AGBT) meetings as well as a “Systems Biology of Gene Regulation and Genome Editing” meeting hosted by Cold Spring Harbor Asia. Currently his research is heavily focused on understanding the spectrum of DNA mutations that contribute to human disease through in vivo functional studies.